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pentobarbital will minimize the extent or outcome of pioglitazone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Mysterious.pentobarbital decreases levels of elvitegravir/cobicistat/emtricitabine/tenofovir DF by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Could result in loss of virologic re